Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune-mediated clearance of von Willebrand factor

A. Inbal, I. Bank, A. Zivelin, D. Varon, R. Dardik, R. Shapiro, E. Rosenthal, B. Shenkman, S. Gitel, U. Seligsohn

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with a severe bleeding tendency due to acquired von Willebrand disease (VWD) is presented. Although no underlying disorder has emerged during 6 years of follow-up, an immune-mediated mechanism was responsible for acquired VWD in this patient as demonstrated by detection of von Willebrand factor (VWF)/anti-VWF complexes in the patient's plasma and their removal by protein A-sepharose beads and resumption of normal haemostasis with correction of VWF antigen, VWF activity and VWF multimeric pattern after treatment of the patient with high-dose gammaglobulin. Detection of anti-VWF antibodies in the patient's plasma had a significant impact on the choice of therapeutic intervention to control bleeding.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalBritish Journal of Haematology
Volume96
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • acquired von Willebrand disease

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