Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins

Batia Stark, Marta Jeison, Claude Preudhomme, Pierre Fenaux, Shifra Ash, Yifat Korek, Jerry Stein, Rina Zaizov, Issac Yaniv

Research output: Contribution to journalArticlepeer-review

Abstract

An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML-M7) in one and myelodysplasia transformed to AML-M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML-M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.

Original languageEnglish
Pages (from-to)1082-1086
Number of pages5
JournalBritish Journal of Haematology
Volume118
Issue number4
DOIs
StatePublished - 2002

Keywords

  • Megakaryoblastic leukaemia
  • Trisomy 21
  • Twins

Fingerprint

Dive into the research topics of 'Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins'. Together they form a unique fingerprint.

Cite this