Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins

Batia Stark; Marta Jeison; Claude Preudhomme; Pierre Fenaux; Shifra Ash; Yifat Korek; Jerry Stein; Rina Zaizov; Issac Yaniv

doi:10.1046/j.1365-2141.2002.03756.x

Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins

Batia Stark^*, Marta Jeison, Claude Preudhomme, Pierre Fenaux, Shifra Ash, Yifat Korek, Jerry Stein, Rina Zaizov, Issac Yaniv

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML-M7) in one and myelodysplasia transformed to AML-M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML-M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.

Original language	English
Pages (from-to)	1082-1086
Number of pages	5
Journal	British Journal of Haematology
Volume	118
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2002.03756.x
State	Published - 2002

Keywords

Megakaryoblastic leukaemia
Trisomy 21
Twins

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10.1046/j.1365-2141.2002.03756.x

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title = "Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins",

abstract = "An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML-M7) in one and myelodysplasia transformed to AML-M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML-M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.",

keywords = "Megakaryoblastic leukaemia, Trisomy 21, Twins",

author = "Batia Stark and Marta Jeison and Claude Preudhomme and Pierre Fenaux and Shifra Ash and Yifat Korek and Jerry Stein and Rina Zaizov and Issac Yaniv",

year = "2002",

doi = "10.1046/j.1365-2141.2002.03756.x",

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T1 - Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins

AU - Stark, Batia

AU - Jeison, Marta

AU - Preudhomme, Claude

AU - Fenaux, Pierre

AU - Ash, Shifra

AU - Korek, Yifat

AU - Stein, Jerry

AU - Zaizov, Rina

AU - Yaniv, Issac

PY - 2002

Y1 - 2002

N2 - An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML-M7) in one and myelodysplasia transformed to AML-M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML-M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.

AB - An intrauterine origin of childhood acute lymphoblastic leukaemia (ALL) was proven by the identical clonotypic gene rearrangement in the concordant leukaemias of monozygotic twins, arising from a single clonogenic progeny. The monozygotic twins, presented at the age of 22 months with acute megakaryoblastic leukaemia (AML-M7) in one and myelodysplasia transformed to AML-M7 in the other. Leukaemic cells in both twins carried trisomy 21 and additional different clonal evolution changes of del(20q) in the first twin and trisomy 8 in the second. AML-M7 of late infancy with trisomy 21 may be included in the leukaemias of intrauterine origin, possibly a result of genotoxic insult.

KW - Megakaryoblastic leukaemia

KW - Trisomy 21

KW - Twins

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Acquired trisomy 21 and distinct clonal evolution in acute megakaryoblastic leukaemia in young monozygotic twins

Abstract

Keywords

UN SDGs

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