Acquired thrombocytopenia after transcatheter aortic valve replacement: Clinical correlates and association with outcomes

Danny Dvir, Philippe Généreux, Israel M. Barbash, Susheel Kodali, Itsik Ben-Dor, Mathew Williams, Rebecca Torguson, Ajay J. Kirtane, Sa'ar Minha, Salem Badr, Lakshmana K. Pendyala, Joshua P. Loh, Petros G. Okubagzi, Jessica N. Fields, Ke Xu, Fang Chen, Rebecca T. Hahn, Lowell F. Satler, Craig Smith, Augusto D. PichardMartin B. Leon, Ron Waksman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: This study aimed to evaluate incidence and correlates for low platelet count after transcatheter aortic valve replacement (TAVR) and to determine a possible association between acquired thrombocytopenia and clinical outcomes. Methods and results: Patients undergoing TAVR from two medical centres were included in the study. They were stratified according to nadir platelet count post procedure: no/mild thrombocytopenia, ≥100 × 109/L; moderate, 50-99 × 109/L; and severe, <50 × 109/L. A total of 488 patients composed of the study population (age 84.7 ± 7.5 years). At a median time of 2 days after TAVR, 176 patients (36.1%) developed significant thrombocytopenia: 149 (30.5%) moderate; 27 patients (5.5%) severe. Upon discharge, the vast majority of patients (90.2%) had no/mild thrombocytopenia. Nadir platelet count <50 × 109/L was highly specific (96.3%), and a count <150 × 109/L highly sensitive (91.2%), for predicting 30-day death (C-statistic 0.76). Patients with severe acquired thrombocytopenia had a significantly higher mortality rate at 1 year (66.7% for severe vs. 16.0% for no/mild vs. 20.1% for moderate; P < 0.001). In multivariate logistic regression, severe thrombocytopenia was independently associated with 1-year mortality (hazard ratio 3.44, CI: 1.02-11.6; P = 0.046). Conclusions: Acquired thrombocytopenia was common after TAVR and was mostly resolved at patient discharge. The severity of thrombocytopenia after TAVR could be used as an excellent, easily obtainable, marker for worse short- and long-term outcomes after the procedure.

Original languageEnglish
Pages (from-to)2663-2671
Number of pages9
JournalEuropean Heart Journal
Volume35
Issue number38
DOIs
StatePublished - 7 Oct 2014
Externally publishedYes

Keywords

  • Thrombocytopenia
  • Transcatheter aortic valve replacement

Fingerprint

Dive into the research topics of 'Acquired thrombocytopenia after transcatheter aortic valve replacement: Clinical correlates and association with outcomes'. Together they form a unique fingerprint.

Cite this