Acoustical structured illumination for super-resolution ultrasound imaging

Tali Ilovitsh, Asaf Ilovitsh, Josquin Foiret, Brett Z. Fite, Katherine W. Ferrara*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Structured illumination microscopy is an optical method to increase the spatial resolution of wide-field fluorescence imaging beyond the diffraction limit by applying a spatially structured illumination light. Here, we extend this concept to facilitate super-resolution ultrasound imaging by manipulating the transmitted sound field to encode the high spatial frequencies into the observed image through aliasing. Post processing is applied to precisely shift the spectral components to their proper positions in k-space and effectively double the spatial resolution of the reconstructed image compared to one-way focusing. The method has broad application, including the detection of small lesions for early cancer diagnosis, improving the detection of the borders of organs and tumors, and enhancing visualization of vascular features. The method can be implemented with conventional ultrasound systems, without the need for additional components. The resulting image enhancement is demonstrated with both test objects and ex vivo rat metacarpals and phalanges.

Original languageEnglish
Article number3
JournalCommunications Biology
Issue number1
StatePublished - 1 Dec 2018
Externally publishedYes


FundersFunder number
National Institutes of HealthNIHR01CA134659, NIHR01CA210553, NIHR01CA112356, NIHR01CA211602
National Cancer InstituteR01CA199658


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