Acinetobacter baumannii Bloodstream Infections: A Nationwide Study in Israel

Amir Nutman*, Elizabeth Temkin, Liat Wullfhart, Vered Schechner, Mitchell J. Schwaber, Yehuda Carmeli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Acinetobacter baumannii (Ab) bloodstream infections (BSIs) are a major public health concern and associated with high mortality. We describe the nationwide incidence, antimicrobial resistance, and mortality of Ab-BSI in Israel using laboratory-based BSI surveillance data from January 2018 to December 2019. During the study period, there were 971 Ab-BSI events (508 in 2018 and 463 in 2019), with an average annual incidence of 8.08/100,000 population. The median age of patients was 72 (IQR 62–83), and 56.4% were males. Two-thirds of Ab-BSI events were hospital-onset (HO), with median day of onset 16 (IQR 9–30). HO-BSI incidence was 0.62/10,000 patient-days (rate per 10,000 patient-days: 2.78, 1.17, and 0.2 for intensive care, medical, and surgical wards, respectively). Carbapenem susceptibility was 23.4%; 41.4% and 14.9% in community and HO events, respectively. The 14-day, 30-day, and 1-year mortality were 51.2%, 59.3%, and 81.4%, respectively. Carbapenem-resistant Ab-BSI were associated with a significantly higher 14-day, 30-day, and 1-year mortality (p < 0.001 for all). In the multivariable model, age (aHR 1.02) and carbapenem resistance (aHR 3.21) were independent predictors of 30-day mortality. In conclusion, Ab-BSIs pose a significant burden with high mortality, especially associated with antimicrobial resistance. Attention should be focused on prevention and improving treatment.

Original languageEnglish
Article number2178
JournalMicroorganisms
Volume11
Issue number9
DOIs
StatePublished - Sep 2023

Keywords

  • Acinetobacter baumannii
  • antimicrobial resistance
  • bloodstream infection
  • carbapenem resistance
  • incidence
  • mortality
  • population-based study

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