TY - JOUR
T1 - Achondroplasia with ankylosing spondylitis
AU - Randolph, L. M.
AU - Shohat, M.
AU - Miller, D.
AU - Lachman, R.
AU - Rimoin, D. L.
PY - 1988
Y1 - 1988
N2 - A 41-year-old-white man with achondroplasia has been followed intermittently since age 27. During this time, he has complained of neck and back pain with limited mobility in both. Other problems have included temporomandibular joint pain, dysuria without apparent urinary tract infection iritis, anemia, and an elevated gamma globulin fraction. Recently he returned to the clinic complaining of rigidity of the entire spine. Radiographs showed complete fusion of the sacroiliac joints and fusion of the cervical vertebral bodies and apophyseal joints, consistent with ankylosing spondylitis. He was found to be HLA B-27 positive. This case illustrates the importance of considering other diseases whenever atypical orthopedic problems arise in patients with a bone dysplasia.
AB - A 41-year-old-white man with achondroplasia has been followed intermittently since age 27. During this time, he has complained of neck and back pain with limited mobility in both. Other problems have included temporomandibular joint pain, dysuria without apparent urinary tract infection iritis, anemia, and an elevated gamma globulin fraction. Recently he returned to the clinic complaining of rigidity of the entire spine. Radiographs showed complete fusion of the sacroiliac joints and fusion of the cervical vertebral bodies and apophyseal joints, consistent with ankylosing spondylitis. He was found to be HLA B-27 positive. This case illustrates the importance of considering other diseases whenever atypical orthopedic problems arise in patients with a bone dysplasia.
UR - http://www.scopus.com/inward/record.url?scp=0023769450&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320310113
DO - 10.1002/ajmg.1320310113
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AN - SCOPUS:0023769450
VL - 31
SP - 117
EP - 121
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
SN - 0148-7299
IS - 1
ER -