TY - JOUR
T1 - Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation
AU - Brenner, Talma
AU - Nizri, Eran
AU - Irony-Tur-Sinai, Michal
AU - Hamra-Amitay, Yasmine
AU - Wirguin, Itzhak
N1 - Funding Information:
We thank Association Francais counter les Myopathies (AFM) for financial support.
PY - 2008/9/15
Y1 - 2008/9/15
N2 - The cholinergic network affects various cellular functions including neurotransmission, and immune reactions. In Myasthenia Gravis (MG), diagnosis and symptomatic therapy are based on cholinergic modulation by acetylcholinesterase inhibitors (AChEI). In Alzheimer's disease (AD) a neurodegenerative disorder associated with inflammatory pathology, cholinergic systems cell loss occurs early. Treatments with special AChEI enhance cholinergic transmission and may act as anti-inflammatory agent via immunocompetent cells expressing α-7 acetylcholine receptor (AChR). In Multiple Sclerosis (MS) an inflammatory T-cell-mediated disease, demyelination and neurodegeneration follow neuroinflammation. MS treatment includes anti-inflammatory and immunomodulatory drugs. AChEI can induce cholinergic up-regulation with subsequent effect on neuroinflammation via α-7-AChR expressing cells. These effects are additional to the cognitive benefit induced by AChEI.
AB - The cholinergic network affects various cellular functions including neurotransmission, and immune reactions. In Myasthenia Gravis (MG), diagnosis and symptomatic therapy are based on cholinergic modulation by acetylcholinesterase inhibitors (AChEI). In Alzheimer's disease (AD) a neurodegenerative disorder associated with inflammatory pathology, cholinergic systems cell loss occurs early. Treatments with special AChEI enhance cholinergic transmission and may act as anti-inflammatory agent via immunocompetent cells expressing α-7 acetylcholine receptor (AChR). In Multiple Sclerosis (MS) an inflammatory T-cell-mediated disease, demyelination and neurodegeneration follow neuroinflammation. MS treatment includes anti-inflammatory and immunomodulatory drugs. AChEI can induce cholinergic up-regulation with subsequent effect on neuroinflammation via α-7-AChR expressing cells. These effects are additional to the cognitive benefit induced by AChEI.
KW - Acetylcholinesterase inhibitors
KW - Alzheimer's disease
KW - Inflammation
KW - Multiple Sclerosis
KW - Myasthenia Gravis
KW - α-7-Acetylcholine receptor
UR - http://www.scopus.com/inward/record.url?scp=51849146029&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2008.05.022
DO - 10.1016/j.jneuroim.2008.05.022
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C2 - 18684515
AN - SCOPUS:51849146029
SN - 0165-5728
VL - 201-202
SP - 121
EP - 127
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - C
ER -
