TY - JOUR
T1 - Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis
AU - Asher, Orna
AU - Neumann, Drorit
AU - Witzemann, Veit
AU - Fuchs, Sara
N1 - Funding Information:
AcknowledgementWs:e thankP rofessorB . Sakmannf or encourage-menta nd fruitful discussionsP, rofessorS . Heinemannfo r the mouse AChR probes,P rofessorU . Nude1fo r thec Y-actinp robe,a nd D. Bar-than for excellentte chnicala ssistanceT. his researchw as supported by grantsf rom the Los AngelesC haptero f the MyastheniaG ravis Foundation, the Muscular DystrophyA ssociationof America, the AssociationF rancaiseC ontrel es Myopathies( AFM), and the United States-IsraeBl inationalS cienceF oundation( BSF).
PY - 1990/7/16
Y1 - 1990/7/16
N2 - Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α-, β-, ε{lunate}-, and δ-subunit specific mRNAs (5.2-, 1.6-, 3.2- and 3.7-fold, respectively), which code for the adult type of AChR (α2βε{lunate}δ) was observed in EAMG in rats. The γ-subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation.
AB - Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α-, β-, ε{lunate}-, and δ-subunit specific mRNAs (5.2-, 1.6-, 3.2- and 3.7-fold, respectively), which code for the adult type of AChR (α2βε{lunate}δ) was observed in EAMG in rats. The γ-subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation.
KW - Adult and embryonic acetylcholine receptor
KW - Experimental autoimmune myasthenia gravis
KW - Subunit transcript
UR - http://www.scopus.com/inward/record.url?scp=0025285780&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(90)80932-9
DO - 10.1016/0014-5793(90)80932-9
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C2 - 2379584
AN - SCOPUS:0025285780
SN - 0014-5793
VL - 267
SP - 231
EP - 235
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -