Abstract
In Krebs solution, histamine evokes in human bladder detrusor muscle strips a dose-dependent contractile response which consists of two pharmacologically distinct responses: a high-sensitivity response evoked at 0.4-2 μM histamine, which is potentiated by neostigmine (0.1 μM) or blocked by atropine (0.1 μM) or ranitidine (1 μM); a low-sensitivity response evoked at 4-40 μM histamine and blocked by dimethindene or diphenhydramine. The findings suggest that the contractile response to low doses of histamine is mediated by acetylcholine released from a site proximal to the muscle. This effect of histamine seems to be mediated by a site which is insensitive to the H1 antagonists dimethindene and diphenhydramine but blocked by the H2 antagonist ranitidine.
Original language | English |
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Pages (from-to) | 45-50 |
Number of pages | 6 |
Journal | European Journal of Pharmacology |
Volume | 142 |
Issue number | 1 |
DOIs | |
State | Published - 6 Oct 1987 |
Keywords
- (Human)
- Acetylcholine
- Atropine
- Bladder
- Detrusor muscle
- Dimethindene
- Diphenhydramine
- Histamine
- Neostigmine
- Ranitidine