Acetylcholine mediation of the contractile response to histamine in human bladder detrusor muscle

Rachel Rubinstein, Israel Nissenkorn, Sasson Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In Krebs solution, histamine evokes in human bladder detrusor muscle strips a dose-dependent contractile response which consists of two pharmacologically distinct responses: a high-sensitivity response evoked at 0.4-2 μM histamine, which is potentiated by neostigmine (0.1 μM) or blocked by atropine (0.1 μM) or ranitidine (1 μM); a low-sensitivity response evoked at 4-40 μM histamine and blocked by dimethindene or diphenhydramine. The findings suggest that the contractile response to low doses of histamine is mediated by acetylcholine released from a site proximal to the muscle. This effect of histamine seems to be mediated by a site which is insensitive to the H1 antagonists dimethindene and diphenhydramine but blocked by the H2 antagonist ranitidine.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalEuropean Journal of Pharmacology
Volume142
Issue number1
DOIs
StatePublished - 6 Oct 1987

Keywords

  • (Human)
  • Acetylcholine
  • Atropine
  • Bladder
  • Detrusor muscle
  • Dimethindene
  • Diphenhydramine
  • Histamine
  • Neostigmine
  • Ranitidine

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