Acetylcholine and cholinergic modulation of immune responses

Eran Nizri, Talma Brenner*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-cell signaling in almost all life forms. ACh was first proposed as a mediator of cellular function by Hunt in 1907, and in 1914 Dale pointed that its action mimicked the response of parasympathetic nerve stimulation (Dale 1914). Loewi, in 1921provided evidence for ACh release by nerve stimulation (Siegel et al. 1998). Furthermore, Dale’s experiments showed that separate receptors can explain the variety of actions of ACh. Subtyping of the receptors was based on the pharmacological activity of two alkaloids: Nicotine and muscarine.

Original languageEnglish
Title of host publicationNerve-Driven Immunity
Subtitle of host publicationNeurotransmitters and Neuropeptides in the Immune System
PublisherSpringer-Verlag Wien
Number of pages24
ISBN (Electronic)9783709108888
ISBN (Print)9783709108871
StatePublished - 1 Jan 2012
Externally publishedYes


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