Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernible

Gavriel Barkai, Elinor Goshen, S. Tzila Zwas, Ornah T. Dolberg, Chaim G. Pick, Omer Bonne, Shaul Schreiber

Research output: Contribution to journalArticlepeer-review

Abstract

A patient suffering from aggressive personality changes and cognitive impairment following head trauma, without neurological or anatomical imaging findings, underwent neuroSPECT scans with and without acetazolamide injection, both before treatment and during treatment with valproate. Acetazolamide injection induced increased prefrontal perfusion not evident at baseline. Valproate treatment was associated with increased prefrontal perfusion concomitant with clinical improvement and abolished response to acetazolamide challenge.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume132
Issue number3
DOIs
StatePublished - 30 Dec 2004

Keywords

  • Acetazolamide
  • Minimal traumatic brain injury (mTBI)
  • Single photon emission computed tomography

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