Accurate identification and selective removal of rotavirus using a plasmonic-magnetic 3D graphene oxide architecture

Zhen Fan, Brian Yust, Bhanu Priya Viraka Nellore, Sudarson Sekhar Sinha, Rajashekhar Kanchanapally, Rebecca A. Crouch, Avijit Pramanik, Suhash Reddy Chavva, Dhiraj Sardar, Paresh Chandra Ray*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

According to the World Health Organization, even in the 21st century, more than one million children die each year due to the rotavirus contamination of drinking water. Therefore, accurate identification and removal of rotavirus are very important to save childrens' lives. Driven by the need, in this Letter, we report for the first time highly selective identification and removal of rotavirus from infected water using a bioconjugated hybrid graphene oxide based three-dimensional (3D) solid architecture. Experimental results show that due to the presence of a high intensity of "hot spots" in the 3D network, an antibodyattached 3D plasmonic-magnetic architecture can be used for accurate identification of rotavirus using surface-enhanced Raman spectroscopy (SERS). Reported data demonstrate that the antibody-attached 3D network binds strongly with rotavirus and is capable of highly efficient removal of rotavirus, which has been confirmed by SERS, fluorescence imaging, and enzyme-linked immunosorbent assay (ELISA) data.

Original languageEnglish
Pages (from-to)3216-3221
Number of pages6
JournalJournal of Physical Chemistry Letters
Volume5
Issue number18
DOIs
StatePublished - 18 Sep 2014
Externally publishedYes

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