Accumulation of closed-circular polyoma DNA molecules containing host DNA during serial passage of the virus

Sara Lavi*, Ernest Winocour

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The high-multiplicity serial passage of plaque-purified polyoma virus in baby mouse kidney cultures results in the accumulation of closed-circular virus DNA molecules containing covalently linked sequences homologous to reiterated mouse cell DNA. Such molecules can be encapsidated within virions and are probably defective in plaque formation.

Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalVirology
Volume57
Issue number1
DOIs
StatePublished - Jan 1974
Externally publishedYes

Funding

FundersFunder number
National Cancer Institute
U.S. Public Health ServiceROI-CA14530-01

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