Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes

Ofer Gemer*, Shmuel Segal, Octav Segal, Efraim Zohav, Essi Sassoon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy. Case: A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery. Conclusion: This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.

Original languageEnglish
Pages (from-to)810-811
Number of pages2
JournalObstetrics and Gynecology
Issue number5
StatePublished - May 1993
Externally publishedYes


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