Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-d-aspartate

Hanan Frenk, Alex Liban, Gideon Urca, Vivian I. Teichberg

Research output: Contribution to journalArticlepeer-review

Abstract

Three compounds reportedly blocking the N-methyl-d-aspartate (NMDA) receptor, namely 2-amino-5-phosphonovalerate, γ-d-glutamylglycine and 3-hydroxy-2-quinoxalinecarboxylic acid, were injected subdurally onto the cortex of freely moving rats. All 3 compounds effectively suppressed behavioral and electrographic seizure activity induced by strychnine, morphine and picrotoxin that were administered via the same route. The cortical application of the NMDA-receptor antagonists did not induce behavioral or electrographic changes, and behavioral side-effects commonly observed following intracerebroventricular administration of these compounds were absent. The anatomical separation of anticonvulsant action and side-effects induced by these compounds suggests that this class of compounds may eventually be useful as antiepileptic drugs.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalBrain Research
Volume373
Issue number1-2
DOIs
StatePublished - 14 May 1986

Keywords

  • 2-amino-5-phosphonovalerate
  • 3-hydroxy-2-quinoxalinecarboxylic acid
  • anticonvulsant
  • epilepsy
  • γ-d-glutamylglycine

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