Abortifacient potential for the epigeal parts of Peganum harmala

Zvia Shapira*, J. Terkel, Y. Egozi, A. Nyska, J. Friedman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of methanol and acetone extracts of the epigeal parts of Peganum harmala, a common medicinal plant among Bedouins in Israel, was studied on several parameters of reproduction in female rats. The methanol extract at a dose of 2.5 g/kg/day, offered in food or in drinking suspension for 30 days, significantly prolonged diestrus by 1.0 day. The methanol extracts at doses of 2.0, 2.5 and 3.5 g/kg/day appeared to produce a dose-dependent significant decrease in litter size. No change in the physical and nutritional status of the animals and no adverse toxicological effects were observed.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalJournal of Ethnopharmacology
Issue number3
StatePublished - Dec 1989


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