Abstract
The effects of oxotremorine in mice were prevented by l-DOPA pretreatment. When l-DOPA was given with carbidopa it abolished oxotremorine-induced catalepsy and tremor but not diarrhoea and lachrymation. When l-DOPA was given with fusaric acid it had a similar effect to l-DOPA given with carbidopa. Noradrenaline and dopamine, on the other hand, antagonized only diarrhoea and lachrymation. 5-Hydroxytryptophan was ineffective against oxotremorine. It is concluded that l-DOPA pretreatment abolished catalepsy and tremor induced by oxotremorine through a central action, whereas diarrhoea and lachrymation are prevented by noradrenaline to which l-DOPA is converted.
| Original language | English |
|---|---|
| Pages (from-to) | 601-603 |
| Number of pages | 3 |
| Journal | Neuropharmacology |
| Volume | 18 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1979 |
