Abolition of oxotremorine effects by l-DOPA pretreatment

A. D. Korczyn, Y. Eshel

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of oxotremorine in mice were prevented by l-DOPA pretreatment. When l-DOPA was given with carbidopa it abolished oxotremorine-induced catalepsy and tremor but not diarrhoea and lachrymation. When l-DOPA was given with fusaric acid it had a similar effect to l-DOPA given with carbidopa. Noradrenaline and dopamine, on the other hand, antagonized only diarrhoea and lachrymation. 5-Hydroxytryptophan was ineffective against oxotremorine. It is concluded that l-DOPA pretreatment abolished catalepsy and tremor induced by oxotremorine through a central action, whereas diarrhoea and lachrymation are prevented by noradrenaline to which l-DOPA is converted.

Original languageEnglish
Pages (from-to)601-603
Number of pages3
JournalNeuropharmacology
Volume18
Issue number7
DOIs
StatePublished - Jul 1979

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