Abnormal uterine bleeding with normal uterine fluid level of human decidua-associated protein 200 reflects normal endometrial histology

Remit Halperin, David Schneider, Ron Maymon, Ian Bukovsky, Eran Hadas

Research output: Contribution to journalArticlepeer-review

Abstract

In the current study, the uterine fluid level of human decidua-associated protein (hDP) 200 was measured in 80 women with abnormal uterine bleeding and normal histology. In 20 women the level of hDP200 was also correlated with the endometrial thickness measured by transvaginal ultrasonography. The results demonstrated the same distribution and similar levels of uterine fluid hDP200 throughout the menstrual cycle as in regularly cycling women, with no correlation between the levels of hDP200 and the endometrial thickness. Thus, the test for uterine fluid hDP200 could serve to discriminate between benign and pathological examinations of endometrial biopsies in women of reproductive age, women with abnormal uterine bleeding and benign conditions of the endometrium. Very low levels of hDP200 are indicative of endometrial hyperplasia or carcinoma.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume42
Issue number1
DOIs
StatePublished - 26 Feb 1996

Keywords

  • Abnormal uterine bleeding
  • Endometrial histology
  • Endometrial thickness
  • Human decidua-associated protein 200
  • Uterine fluid

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