Abnormal thermoregulation in drug-free male schizophrenia patients

Roni Shiloh, Abraham Weizman*, Yoram Epstein, Sara Lea Rosenberg, Avi Valevski, Pnina Dorfman-Etrog, Nehama Wiezer, Nachum Katz, Hanan Munitz, Haggai Hermesh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Schizophrenia patients may develop various thermoregulatory disturbances. We hypothesized that a standardized exercise-heat tolerance test [two 50-min bouts of walking a motor-driven treadmill at 40°C (relative humidity=40%)] would reveal abnormal thermoregulation in drug-free schizophrenia patients. Six drug-free schizophrenia outpatients and seven healthy comparison subjects participated in this study. The schizophrenia patients exhibited significantly higher baseline and exertion-related rectal temperature. The relevance of these findings to the pathophysiology of schizophrenia-related thermoregulatory disorders is as yet unclear.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalEuropean Neuropsychopharmacology
Issue number4
StatePublished - 2001


  • Heat-stress
  • Schizophrenia
  • Thermoregulation


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