Abnormal nuchal translucency followed by normal microarray analysis is associated with placental pathology-related complications

Eyal Krispin, Anya Kushnir, Asaf Shemer, Shlomit Rienstein, Michal Berkenstadt, Yoav Yinon, Boaz Weisz

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Identify placental pathology-related complications, labor and neonatal outcomes in pregnancies complicated by pathological nuchal translucency (NT) with normal microarray analysis. Methods: A retrospective study in which all women with singleton pregnancy who demonstrated NT above 3 mm and a normal microarray analysis were matched to women with normal NT and a normal microarray analysis (2013–2019) in a single tertiary academic center. The following placental pathology-related parameters were measured: preeclampsia, oligohydramnios, suspected intrauterine growth restriction, abnormal Doppler studies or small for gestational age (SGA) neonates. The primary outcome was defined as a composite of complications related to placental pathology including preeclampsia and SGA neonate. Secondary outcomes were labor complications and neonatal morbidity. Results: A total of 185 women were included in the study: of them, 47 presented an abnormal NT (study group) and 138 presented normal NT (controls). Groups did not significantly differ in baseline characteristics. Regarding primary outcome, all placental-related complications frequencies were higher in the study group, with a composite rate of 17.02% versus 6.52% in controls (p = 0.042%). Secondary outcomes did not differ between groups. Conclusions: Abnormal NT measurement presented in pregnancies with normal fetal microarray analysis is associated with higher rates of placental-related complications.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalPrenatal Diagnosis
Volume41
Issue number7
DOIs
StatePublished - Jun 2021

Keywords

  • chromosomal microarray analysis
  • fetus
  • nuchal translucency
  • placental complications

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