TY - JOUR
T1 - Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease
AU - Gafter, U.
AU - Kessler, E.
AU - Shabtay, F.
AU - Shaked, P.
AU - Djaldetti, M.
PY - 1980
Y1 - 1980
N2 - A patient with alpha heavy chain disease (αHCD), who showed an abnormal chromosomal marker (D14 q+) in 10% of the bone marrow cells, is described. The mesenteric lymph nodes, which showed reactive hyperplasia in the first biopsy, transformed later to a malignant lymphoma and finally to a plasma cell tumor. The small intestine revealed villous atrophy, diminished crypts, and intact surface epithelium. The ultrastructure of the goblet and epithelial cells appeared to be normal, and the microvilli were preserved except for circumscribed areas of destruction. The lamina propria was heavily infiltrated with mononuclear cells, mainly mature plasma cells. Alpha heavy chains (αHC) were found in the patient's saliva.
AB - A patient with alpha heavy chain disease (αHCD), who showed an abnormal chromosomal marker (D14 q+) in 10% of the bone marrow cells, is described. The mesenteric lymph nodes, which showed reactive hyperplasia in the first biopsy, transformed later to a malignant lymphoma and finally to a plasma cell tumor. The small intestine revealed villous atrophy, diminished crypts, and intact surface epithelium. The ultrastructure of the goblet and epithelial cells appeared to be normal, and the microvilli were preserved except for circumscribed areas of destruction. The lamina propria was heavily infiltrated with mononuclear cells, mainly mature plasma cells. Alpha heavy chains (αHC) were found in the patient's saliva.
UR - http://www.scopus.com/inward/record.url?scp=0018903755&partnerID=8YFLogxK
U2 - 10.1136/jcp.33.2.136
DO - 10.1136/jcp.33.2.136
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 6767755
AN - SCOPUS:0018903755
SN - 0021-9746
VL - 33
SP - 136
EP - 144
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 2
ER -