Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease

U. Gafter, E. Kessler, F. Shabtay, P. Shaked, M. Djaldetti

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A patient with alpha heavy chain disease (αHCD), who showed an abnormal chromosomal marker (D14 q+) in 10% of the bone marrow cells, is described. The mesenteric lymph nodes, which showed reactive hyperplasia in the first biopsy, transformed later to a malignant lymphoma and finally to a plasma cell tumor. The small intestine revealed villous atrophy, diminished crypts, and intact surface epithelium. The ultrastructure of the goblet and epithelial cells appeared to be normal, and the microvilli were preserved except for circumscribed areas of destruction. The lamina propria was heavily infiltrated with mononuclear cells, mainly mature plasma cells. Alpha heavy chains (αHC) were found in the patient's saliva.

Original languageEnglish
Pages (from-to)136-144
Number of pages9
JournalJournal of Clinical Pathology
Volume33
Issue number2
DOIs
StatePublished - 1980

Fingerprint

Dive into the research topics of 'Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease'. Together they form a unique fingerprint.

Cite this