Abdominal CT findings in nephropathic amyloidosis of familial Mediterranean fever

S. Apter, D. Zemer, A. Terhakopian, G. Gayer, P. Langevitz, M. Amitai, T. Schwartz, E. Atar, M. Hertz, M. Pras, A. Livneh

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the abdominal CT features of reactive amyloidosis, abdominal CT scans of 2O patients with amyloidosis of familial Mediterranean fever (FMF) were reviewed and compared with abdominal CT scans of 2 control groups: 22 patients with chronic renal failure (CRF) due to non-amyloidotic kidney diseases and 40 patients with normal kidney function. The kidney size of patients with amyloidosis of FMF were found to vary during the course of the disease from normal or slightly larger than normal at the proteinuric phase, to smaller than normal and comparable to kidney size in CRF, at the uremic stage. Compared to kidney disease of other causes, more patients with FMF-amyloidosis had dense kidneys with coarse parenchymal calcification and calcification in other abdominal organs. Patients with FMF-amyloidosis had fewer aortic calcifications than patients with non-amyloidotic kidney disease. These findings suggest that kidney disease of reactive amyloidosis may have abdominal CT findings distinguishing it from other types of kidney diseases.

Original languageEnglish
Pages (from-to)58-64
Number of pages7
JournalAmyloid
Volume8
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Calcifications
  • Chronic renal failure
  • Colchicine
  • Computed tomography
  • Familial Mediterranean fever
  • Proteinuria

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