A woman with mycosis fungoides, vitiligo, and a new hand nodule

  • Joelle Feghali
  • , Leore Lavin
  • , Spencer Ng
  • , Konstantinos Linos
  • , Shamir Geller*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion. The lesion was diagnosed as an eccrine porocarcinoma (EPC). The occurrence of EPCs following radiotherapy or trauma has been documented. This case highlights the importance of considering EPCs in patients with extensive skin treatments and immunosuppression history.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalInternational Journal of Dermatology
Volume64
Issue number3
DOIs
StatePublished - Mar 2025
Externally publishedYes

Funding

FundersFunder number
National Institutes of Health
National Cancer InstituteP30 CA008748

    Keywords

    • eccrine
    • mycosis fungoides
    • skin cancer
    • skin of color (SOC)
    • vitiligo

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