A woman with mycosis fungoides, vitiligo, and a new hand nodule

Joelle Feghali; Leore Lavin; Spencer Ng; Konstantinos Linos; Shamir Geller

doi:10.1111/ijd.17552

A woman with mycosis fungoides, vitiligo, and a new hand nodule

Joelle Feghali
, Leore Lavin
, Spencer Ng
, Konstantinos Linos
, Shamir Geller^*

^*Corresponding author for this work

Université libre de Bruxelles
University of Balamand
Memorial Sloan-Kettering Cancer Center
Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

Abstract

A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion. The lesion was diagnosed as an eccrine porocarcinoma (EPC). The occurrence of EPCs following radiotherapy or trauma has been documented. This case highlights the importance of considering EPCs in patients with extensive skin treatments and immunosuppression history.

Original language	English
Pages (from-to)	513-516
Number of pages	4
Journal	International Journal of Dermatology
Volume	64
Issue number	3
DOIs	https://doi.org/10.1111/ijd.17552
State	Published - Mar 2025
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health
National Cancer Institute	P30 CA008748

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

eccrine
mycosis fungoides
skin cancer
skin of color (SOC)
vitiligo

Access to Document

10.1111/ijd.17552

Cite this

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title = "A woman with mycosis fungoides, vitiligo, and a new hand nodule",

abstract = "A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion. The lesion was diagnosed as an eccrine porocarcinoma (EPC). The occurrence of EPCs following radiotherapy or trauma has been documented. This case highlights the importance of considering EPCs in patients with extensive skin treatments and immunosuppression history.",

keywords = "eccrine, mycosis fungoides, skin cancer, skin of color (SOC), vitiligo",

author = "Joelle Feghali and Leore Lavin and Spencer Ng and Konstantinos Linos and Shamir Geller",

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doi = "10.1111/ijd.17552",

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AU - Lavin, Leore

AU - Ng, Spencer

AU - Linos, Konstantinos

AU - Geller, Shamir

PY - 2025/3

Y1 - 2025/3

N2 - A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion. The lesion was diagnosed as an eccrine porocarcinoma (EPC). The occurrence of EPCs following radiotherapy or trauma has been documented. This case highlights the importance of considering EPCs in patients with extensive skin treatments and immunosuppression history.

AB - A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion. The lesion was diagnosed as an eccrine porocarcinoma (EPC). The occurrence of EPCs following radiotherapy or trauma has been documented. This case highlights the importance of considering EPCs in patients with extensive skin treatments and immunosuppression history.

KW - eccrine

KW - mycosis fungoides

KW - skin cancer

KW - skin of color (SOC)

KW - vitiligo

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A woman with mycosis fungoides, vitiligo, and a new hand nodule

Abstract

Funding

UN SDGs

Keywords

Access to Document

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