TY - JOUR
T1 - A-to-I RNA editing in honeybees shows signals of adaptation and convergent evolution
AU - Duan, Yuange
AU - Dou, Shengqian
AU - Porath, Hagit T.
AU - Huang, Jiaxing
AU - Eisenberg, Eli
AU - Lu, Jian
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2021/1/22
Y1 - 2021/1/22
N2 - Social insects exhibit extensive phenotypic diversities among the genetically similar individuals, suggesting a role for the epigenetic regulations beyond the genome level. The ADAR-mediated adenosine-to-inosine (A-to-I) RNA editing, an evolutionarily conserved mechanism, facilitates adaptive evolution by expanding proteomic diversities. Here, we characterize the A-to-I RNA editome of honeybees (Apis mellifera), identifying 407 high-confidence A-to-I editing sites. Editing is most abundant in the heads and shows signatures for positive selection. Editing behavior differs between foragers and nurses, suggesting a role for editing in caste differentiation. Although only five sites are conserved between bees and flies, an unexpectedly large number of genes exhibit editing in both species, albeit at different locations, including the nonsynonymous auto-editing of Adar. This convergent evolution, where the same target genes independently acquire recoding events in distant diverged clades, together with the signals of adaptation observed in honeybees alone, further supports the notion of recoding being adaptive.
AB - Social insects exhibit extensive phenotypic diversities among the genetically similar individuals, suggesting a role for the epigenetic regulations beyond the genome level. The ADAR-mediated adenosine-to-inosine (A-to-I) RNA editing, an evolutionarily conserved mechanism, facilitates adaptive evolution by expanding proteomic diversities. Here, we characterize the A-to-I RNA editome of honeybees (Apis mellifera), identifying 407 high-confidence A-to-I editing sites. Editing is most abundant in the heads and shows signatures for positive selection. Editing behavior differs between foragers and nurses, suggesting a role for editing in caste differentiation. Although only five sites are conserved between bees and flies, an unexpectedly large number of genes exhibit editing in both species, albeit at different locations, including the nonsynonymous auto-editing of Adar. This convergent evolution, where the same target genes independently acquire recoding events in distant diverged clades, together with the signals of adaptation observed in honeybees alone, further supports the notion of recoding being adaptive.
KW - Evolutionary Biology
KW - Genetic Engineering
KW - Genetics
KW - Genomics
UR - http://www.scopus.com/inward/record.url?scp=85098989608&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2020.101983
DO - 10.1016/j.isci.2020.101983
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C2 - 33458624
AN - SCOPUS:85098989608
SN - 2589-0042
VL - 24
JO - iScience
JF - iScience
IS - 1
M1 - 101983
ER -