A synthetic pentasaccharide with GTPase activity

Dmitry Solomon, Micha Fridman, Jeanwei Zhang, Timor Baasov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


(Matrix Presented) The design, synthesis, and preliminary evaluation of the first example of synthetic pentasaccharide (1) that shows marked rate enhancement and specificity for the hydrolysis of GTP to GDP and orthophosphate (OP) are reported. At the concentration ratios of GTP/1 = 3.6 and GTP/Mg2+ = 1 (pH 7.1, 50 °C), a rate enhancement of about 500-fold was obtained.

Original languageEnglish
Pages (from-to)4311-4314
Number of pages4
JournalOrganic Letters
Issue number26
StatePublished - 27 Dec 2001
Externally publishedYes


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