A synthetic pentasaccharide with GTPase activity

Dmitry Solomon; Micha Fridman; Jeanwei Zhang; Timor Baasov

doi:10.1021/ol010257h

A synthetic pentasaccharide with GTPase activity

Dmitry Solomon, Micha Fridman, Jeanwei Zhang, Timor Baasov^*

^*Corresponding author for this work

Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

(Matrix Presented) The design, synthesis, and preliminary evaluation of the first example of synthetic pentasaccharide (1) that shows marked rate enhancement and specificity for the hydrolysis of GTP to GDP and orthophosphate (OP) are reported. At the concentration ratios of GTP/1 = 3.6 and GTP/Mg²⁺ = 1 (pH 7.1, 50 °C), a rate enhancement of about 500-fold was obtained.

Original language	English
Pages (from-to)	4311-4314
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	26
DOIs	https://doi.org/10.1021/ol010257h
State	Published - 27 Dec 2001
Externally published	Yes

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title = "A synthetic pentasaccharide with GTPase activity",

abstract = "(Matrix Presented) The design, synthesis, and preliminary evaluation of the first example of synthetic pentasaccharide (1) that shows marked rate enhancement and specificity for the hydrolysis of GTP to GDP and orthophosphate (OP) are reported. At the concentration ratios of GTP/1 = 3.6 and GTP/Mg2+ = 1 (pH 7.1, 50 °C), a rate enhancement of about 500-fold was obtained.",

author = "Dmitry Solomon and Micha Fridman and Jeanwei Zhang and Timor Baasov",

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AU - Baasov, Timor

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N2 - (Matrix Presented) The design, synthesis, and preliminary evaluation of the first example of synthetic pentasaccharide (1) that shows marked rate enhancement and specificity for the hydrolysis of GTP to GDP and orthophosphate (OP) are reported. At the concentration ratios of GTP/1 = 3.6 and GTP/Mg2+ = 1 (pH 7.1, 50 °C), a rate enhancement of about 500-fold was obtained.

AB - (Matrix Presented) The design, synthesis, and preliminary evaluation of the first example of synthetic pentasaccharide (1) that shows marked rate enhancement and specificity for the hydrolysis of GTP to GDP and orthophosphate (OP) are reported. At the concentration ratios of GTP/1 = 3.6 and GTP/Mg2+ = 1 (pH 7.1, 50 °C), a rate enhancement of about 500-fold was obtained.

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A synthetic pentasaccharide with GTPase activity

Abstract

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