A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation

Sudipta Mondal; Shiv Swaroop; Ramanathan Gurunath; Sandeep Verma

doi:10.1016/j.tetlet.2010.09.047

A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation

Sudipta Mondal, Shiv Swaroop, Ramanathan Gurunath^*, Sandeep Verma

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies.

Original language	English
Pages (from-to)	6111-6115
Number of pages	5
Journal	Tetrahedron Letters
Volume	51
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2010.09.047
State	Published - 24 Nov 2010
Externally published	Yes

Keywords

Fluorescence
Mercury sensing
Mercury sequestration
Self assembly
Tryptophan conjugate

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10.1016/j.tetlet.2010.09.047

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title = "A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation",

abstract = "The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies.",

keywords = "Fluorescence, Mercury sensing, Mercury sequestration, Self assembly, Tryptophan conjugate",

author = "Sudipta Mondal and Shiv Swaroop and Ramanathan Gurunath and Sandeep Verma",

note = "Funding Information: S.M. and S.S. thank the CSIR for senior research fellowship. This work is supported through DST projects to S.V. (Swarnajayanti Fellowship) and R.G. ",

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doi = "10.1016/j.tetlet.2010.09.047",

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AU - Mondal, Sudipta

AU - Swaroop, Shiv

AU - Gurunath, Ramanathan

AU - Verma, Sandeep

N1 - Funding Information: S.M. and S.S. thank the CSIR for senior research fellowship. This work is supported through DST projects to S.V. (Swarnajayanti Fellowship) and R.G.

PY - 2010/11/24

Y1 - 2010/11/24

N2 - The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies.

AB - The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies.

KW - Fluorescence

KW - Mercury sensing

KW - Mercury sequestration

KW - Self assembly

KW - Tryptophan conjugate

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SN - 0040-4039

VL - 51

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EP - 6115

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 47

ER -

A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation

Abstract

Keywords

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