A subpopulation of suppressor cells in Richter's syndrome with both monocytic and T‐lymphocytic characteristics

N. Lahat, E. Aghai, M. Quitt, E. Nir, P. Froom

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated T‐lymphocyte functions in the peripheral blood of a patient with B‐cell chronic lymphocytic leukemia after transformation to large cell lymphoma (Richter's syndrome). A subpopulation of E‐rosette adherent cells were found with T‐lymphocytic surface markers (OKT3+/8+/4+), monocytic characteristics (latex ingestion, nonspecific esterase staining), and suppressor activity. In contrast to the patient's nonadherent T‐cells, this subpopulation suppressed PHA proliferation of autologous lymphocytes, pokeweed mitogen (PWM)‐induced proliferation of normal non‐T cells, and a mixed lymphocyte reaction. Further studies are warranted in patients with Richter's syndrome, in order to determine the frequency and significance of our findings.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalAmerican Journal of Hematology
Volume20
Issue number3
DOIs
StatePublished - Nov 1985
Externally publishedYes

Keywords

  • Richter's syndrome
  • T‐lymphocytes
  • monocytic characteristics
  • suppressor function

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