TY - JOUR
T1 - A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits
AU - Naveh, Nava
AU - Weissman, Channa
AU - Muchtar, Shaul
AU - Benita, Shimon
AU - Mechoulam, Raphael
PY - 2000/4
Y1 - 2000/4
N2 - Purpose: To study the ocular hypotensive effect of a nonpsychotropic cannabinoid, HU-211 (11-hydroxy-Δ8-tetra-hydrocannabinol, dimethylheptyl), an N-methyl-D-aspartate (NMDA) agonist, in normotensive rabbits. Methods: The cannabinoid HU-211, being lipophilic, was incorporated into a stable oil-in-water submicron sterile emulsion, consisting of 0.12% (w/w) HU-211. A single-dose, randomized and double-masked study was designed, using a Digilab 30R pneumotonometer to measure intraocular pressure (IOP) in normotensive rabbits. Results: Application of a single dose of HU-211 ophthalmic preparation resulted in an IOP reduction of 5.3 mmHg (24% of baseline), first evident at 1.5 h post application and persisting for over 6 h. A small but significant lowering of pressure (12.5% of baseline) occurred in the contralateral eyes of HU-211 treated rabbits, lasting for 4 h post treatment. Conclusion: Our work demonstrated that HU-211, incorporated into submicron emulsion, caused a 6-h-long reduction in IOP in the treated eye, with a lesser reduction in the contralateral untreated eye.
AB - Purpose: To study the ocular hypotensive effect of a nonpsychotropic cannabinoid, HU-211 (11-hydroxy-Δ8-tetra-hydrocannabinol, dimethylheptyl), an N-methyl-D-aspartate (NMDA) agonist, in normotensive rabbits. Methods: The cannabinoid HU-211, being lipophilic, was incorporated into a stable oil-in-water submicron sterile emulsion, consisting of 0.12% (w/w) HU-211. A single-dose, randomized and double-masked study was designed, using a Digilab 30R pneumotonometer to measure intraocular pressure (IOP) in normotensive rabbits. Results: Application of a single dose of HU-211 ophthalmic preparation resulted in an IOP reduction of 5.3 mmHg (24% of baseline), first evident at 1.5 h post application and persisting for over 6 h. A small but significant lowering of pressure (12.5% of baseline) occurred in the contralateral eyes of HU-211 treated rabbits, lasting for 4 h post treatment. Conclusion: Our work demonstrated that HU-211, incorporated into submicron emulsion, caused a 6-h-long reduction in IOP in the treated eye, with a lesser reduction in the contralateral untreated eye.
UR - http://www.scopus.com/inward/record.url?scp=0034018676&partnerID=8YFLogxK
U2 - 10.1007/s004170050361
DO - 10.1007/s004170050361
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C2 - 10853933
AN - SCOPUS:0034018676
SN - 0721-832X
VL - 238
SP - 334
EP - 338
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 4
ER -