@article{84a6664604f14e97bd59442509058c73,
title = "A study of four-helix bundles: Investigating protein folding via similar architectural motifs in protein cores and in subunit interfaces",
abstract = "Four-helix bundles are identified and characterized in the subunit interfaces of protein multimers. We find that this motif occurs as often in the interfaces as in the protein monomers. Common and different characteristics demonstrated by the bundles in the two environments suggest the possible stabilization mechanisms of the bundles via cooperative helical twist, dipole alignment and interhelical connections. Nucleation of parallel helix pairs may be a favourable pathway before the pairs couple into bundles during folding. Certain properties found chaotic in the interface four-helix bundles indicate that either the subunit association is far from the global minimum conformation, or that the footprints of the folding pathway are recorded in these properties.",
keywords = "Architectural motif, Four-helix bundle, Protein core, Protein folding, Subunit interface",
author = "Lin, {Shuo Liang} and Tsai, {Chung Jung} and Ruth Nussinov",
note = "Funding Information: We thank Drs Jacob Maizel and Robert Jernigan for interest and helpful discussions. We thank the personnel at the Frederick Cancer Research and Development Center for their assistance. The research of R.N. has been sponsored by the National Cancer Institute, DHHS, under contract no. 1-CO-74102 with Program Resources, Inc., and in part by grant no. 91-00219 from the U.S.–Israel Binational Science Foundation (BSF), Jerusalem, Israel, and by a grant from the Israel Science Foundation administered by the Israel Academy of Sciences. The contents of this publication do not necessarily reflect the views or policies of the DHHS, nor does mention of trade names, commercial products, or organization imply endorsement by the U.S. Government.",
year = "1995",
month = apr,
day = "21",
doi = "10.1006/jmbi.1995.0208",
language = "אנגלית",
volume = "248",
pages = "151--161",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "1",
}