A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity

Udi Nussinovitch*, Aamer Sandoo, Marek Malik

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Atherosclerosis is an ongoing process initiated by endothelial dysfunction and vessel-wall inflammation, ultimately resulting in endovascular lumen narrowing. Myocardial ischemia can result in abnormal cardiac function and increased risk for arrhythmias. Early signs of endothelial dysfunction and subclinical atherosclerosis can be detected by several noninvasive assessments in the microvasculature (laser Doppler imaging with iontophoresis of vasoactive agents) and in the large vessels (flow-mediated dilatation and intima-media thickness). Myocardial anatomy can be measured by other invasive and noninvasive diagnostic modalities such as coronary CT and coronary angiography. Many electrocardiographic tools have been proposed to predict the occurrence of ventricular and supraventricular arrhythmias, eg, T-wave abnormalities, QT variability index, heart-rate turbulence, signal-averaged electrocardiogram, and T-wave alternans. The aim of the current chapter is to review the battery of tests developed for inpatient and outpatient evaluation, for diagnosing clinical or subclinical coronary disease, cardiac structural and functional abnormalities, and for stratifying arrhythmic risk. Hence, this chapter offers a guide to clinicians using toolkits for cardiac testing in patients with either cardiac illnesses or systemic diseases with presumably cardiac involvements.

Original languageEnglish
Title of host publicationThe Heart in Rheumatic, Autoimmune and Inflammatory Diseases
Subtitle of host publicationPathophysiology, Clinical Aspects and Therapeutic Approaches
PublisherElsevier Inc.
Number of pages35
ISBN (Electronic)9780128032688
ISBN (Print)9780128032671
StatePublished - 22 Feb 2017
Externally publishedYes


  • Arrhythmias
  • Electrocardiogram (ECG)
  • Endothelial-dysfunction
  • Flow-mediated dilatation (FMD)
  • T-wave abnormality


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