A structural and dynamic molecular model for the sodium channel of Electrophorus electricus

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Abstract

Chemical logic and single group rotation (SGR) theory are applied to the primary structure determined by Noda [(1984) Nature 312, 121-127] to construct a molecular model of the sodium channel of Electrophorus electricus. Both structural and dynamic aspects of the channel are accounted for, including gating current, sensitivity to changes in membrane potential, channel opening, a binding site for sodium, selectivity for sodium over potassium, capacity for rapid sodium flow, sensitivity to batrachotoxin (or other toxins) and inactivation.

Original languageEnglish
Pages (from-to)234-242
Number of pages9
JournalFEBS Letters
Volume182
Issue number2
DOIs
StatePublished - 25 Mar 1985

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