TY - JOUR
T1 - A structural and dynamic molecular model for the sodium channel of Electrophorus electricus
AU - Kosower, Edward M.
PY - 1985/3/25
Y1 - 1985/3/25
N2 - Chemical logic and single group rotation (SGR) theory are applied to the primary structure determined by Noda [(1984) Nature 312, 121-127] to construct a molecular model of the sodium channel of Electrophorus electricus. Both structural and dynamic aspects of the channel are accounted for, including gating current, sensitivity to changes in membrane potential, channel opening, a binding site for sodium, selectivity for sodium over potassium, capacity for rapid sodium flow, sensitivity to batrachotoxin (or other toxins) and inactivation.
AB - Chemical logic and single group rotation (SGR) theory are applied to the primary structure determined by Noda [(1984) Nature 312, 121-127] to construct a molecular model of the sodium channel of Electrophorus electricus. Both structural and dynamic aspects of the channel are accounted for, including gating current, sensitivity to changes in membrane potential, channel opening, a binding site for sodium, selectivity for sodium over potassium, capacity for rapid sodium flow, sensitivity to batrachotoxin (or other toxins) and inactivation.
UR - http://www.scopus.com/inward/record.url?scp=0021826503&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(85)80306-9
DO - 10.1016/0014-5793(85)80306-9
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AN - SCOPUS:0021826503
SN - 0014-5793
VL - 182
SP - 234
EP - 242
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -