A stochastic model of susceptibility to antibiotic therapy-The effects of cross-resistance and treatment history

Alina Zalounina, Mical Paul, Leonard Leibovici, Steen Andreassen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Selection of antibiotic therapy is a complicated process, depending on, among others, the effect of cross-resistance between antibiotics. We propose a model, which incorporates information about treatment history in the form of information on the success or failure of the current treatment and which combines this with data on cross-resistance to predict the susceptibility to future antibiotic treatments, thus providing a systematic basis for revision of antibiotic treatment. Methods and material: The stochastic model was built as a causal probabilistic network (CPN). Data used in the model were based on a bacteriology database including data on patient and episode unique pathogens cultured from a microbiological sample. Results: In this paper, we develop a CPN that can exploit knowledge about cross-resistance between two consecutive treatments, explore the properties of this CPN and consider how the CPN can be integrated into a complete decision support system for selection of antibiotic therapy. Conclusion: The model presented may be useful both as a theoretical tool describing cross-resistance between antibiotics and as a part of complete decision support system for selection of antibiotic therapy.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalArtificial Intelligence in Medicine
Volume40
Issue number1
DOIs
StatePublished - May 2007
Externally publishedYes

Keywords

  • Antibiotic therapy
  • Bacterial infections
  • Causal probabilistic networks
  • Cross-resistance

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