A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women

Inabr Gal, Gad Kimmel, Ruth Gershoni-Baruch, Moshe Z. Papa, Efrat Dagan, Ron Shamir, Eitan Friedman

Research output: Contribution to journalArticlepeer-review

Abstract

While the precise genes involved in determining familial breast cancer risk in addition to BRCA1/2 are mostly unknown, one strong candidate is RAD51. Jewish non-Ashkenazi women at high-risk for breast/ovarian cancer and ethnically matched controls were genotyped using four single nucleotide polymorphisms spanning the RAD51 genomic region, and the resulting haplotypes were constructed using the GERBIL algorithm. A total of 314 individuals were genotyped: 184 non-Ashkenazi high-risk women (119 with breast cancer), and 130 unaffected, average-risk ethnically matched controls. Using GEBRIL, three frequent haplotypes were constructed. One of the haplotypes (TGTA - coined haplotype 3) was present in 7.3% (19/260 haplotypes) of controls (n = 130) and in 16.8% (40/238 haplotypes) of high-risk breast cancer patients (n = 119, P = 0.001). A specific RAD51 haplotype is more prevalent among non-Ashkenazi Jewish high-risk women than in average-risk population.

Original languageEnglish
Pages (from-to)1129-1134
Number of pages6
JournalEuropean Journal of Cancer
Volume42
Issue number8
DOIs
StatePublished - May 2006

Keywords

  • Association study
  • BRCA1
  • BRCA2
  • Haplotype
  • High-risk population
  • Odds ratio
  • RAD51
  • Relative risk

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