A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats

Victor A. Aniol, Aleksandra Y. Ivanova-Dyatlova, Ora Keren, Alla B. Guekht, Yosef Sarne, Natalia V. Gulyaeva

Research output: Contribution to journalArticlepeer-review

Abstract

According to different studies, between 5% and 10% of people suffer a single isolated seizure episode at some time in their life. However, little is known about the effects of a single seizure episode on cognitive function, and clinical investigations of this issue are not easy to perform. In this situation, animal models may be a reasonable choice. The aim of our study was to follow the time course of delayed effects of generalized clonic-tonic convulsions on learning and memory functions in rats. A clonic-tonic seizure episode was induced by a single i.p. injection of pentylenetetrazole (70. mg/kg). Different behavioral tests were performed between days 10 and 100 after the convulsant administration. A single seizure episode resulted in a gradual decline in short-term memory function as assessed by novel object recognition and social recognition tests. The seizure episode induced a quick increase in hippocampal cell proliferation; however, the excessive newly generated cells seemed to be eliminated by the time of obvious cognitive impairment. These observations are indicative of a slowly developing and long-lasting influence of a single seizure episode on cognitive function. A rather long time period between the seizure episode and the manifestations of cognitive decline provides a window for a possible therapeutic intervention, and an elaboration of such "post-conditioning" treatments may be a promising opportunity to prevent subsequent mental impairments in patients.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalEpilepsy and Behavior
Volume26
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Cognitive impairments
  • Neurogenesis
  • Novel object recognition
  • Pentylenetetrazole
  • Radial arm maze
  • Seizure
  • Social recognition

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