A single low dose of tetrahydrocannabinol induces long-term cognitive deficits

Isabella Tselnicker; Ora Keren; Aya Hefetz; Chaim G. Pick; Yosef Sarne

doi:10.1016/j.neulet.2006.10.033

A single low dose of tetrahydrocannabinol induces long-term cognitive deficits

Isabella Tselnicker, Ora Keren, Aya Hefetz, Chaim G. Pick, Yosef Sarne^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Δ⁹-Tetrahydrocannabinol (THC) was shown to exert either neuroprotective or neurotoxic effects. Based on our in vitro studies and on pharmacokinetic considerations, we have recently presented a hypothesis that explains this dual activity of THC. This explanation is based on the assumption that extremely low doses of cannabinoids are neurotoxic. The present study verifies this assumption and shows that a single injection of 0.001 mg/kg THC (3-4 orders of magnitude lower than conventional doses) significantly affected the performance of mice in the Morris water maze test 3 weeks later. The THC-injected mice showed both longer escape latencies and lower scores in the probe tests compared to their matched controls, indicating the induction of cognitive deficits.

Original language	English
Pages (from-to)	108-111
Number of pages	4
Journal	Neuroscience Letters
Volume	411
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2006.10.033
State	Published - 10 Jan 2007

Keywords

Cannabinoid
Morris water maze
Neurotoxicity
THC
Tetrahydrocannabinol

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10.1016/j.neulet.2006.10.033

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title = "A single low dose of tetrahydrocannabinol induces long-term cognitive deficits",

abstract = "Δ9-Tetrahydrocannabinol (THC) was shown to exert either neuroprotective or neurotoxic effects. Based on our in vitro studies and on pharmacokinetic considerations, we have recently presented a hypothesis that explains this dual activity of THC. This explanation is based on the assumption that extremely low doses of cannabinoids are neurotoxic. The present study verifies this assumption and shows that a single injection of 0.001 mg/kg THC (3-4 orders of magnitude lower than conventional doses) significantly affected the performance of mice in the Morris water maze test 3 weeks later. The THC-injected mice showed both longer escape latencies and lower scores in the probe tests compared to their matched controls, indicating the induction of cognitive deficits.",

keywords = "Cannabinoid, Morris water maze, Neurotoxicity, THC, Tetrahydrocannabinol",

author = "Isabella Tselnicker and Ora Keren and Aya Hefetz and Pick, {Chaim G.} and Yosef Sarne",

note = "Funding Information: This research was supported by The Israel Science Foundation (grant no. 180/04) and by the Israel Ministry of Health (grant no. 5909).",

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AU - Pick, Chaim G.

AU - Sarne, Yosef

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A single low dose of tetrahydrocannabinol induces long-term cognitive deficits

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Keywords

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