A sequence analysis system encompassing rules for DNA helical distortion

Bruce A. Shapiro*, Ruth Nussinov, Lewis E. Lipkin, Jacob V. Maizel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, it has been shown by Calladine (1982) and Dickerson (1983) that DNA distortions due to steric clashes between opposing purines and pyrimidines can be quantitated based upon four sum functions. The distortions involve helical twist, roll, torsion angle variations and propeller twist. It is the contention of the authors that these perturbations in structure act as information carriers for various external DNA interactions. This paper describes a system that incorporates these four rules and various other functions that permit the systematic interactive exploration for significant patterns as a consequence of these steric clashes.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalNucleic Acids Research
Volume14
Issue number1
DOIs
StatePublished - 10 Jan 1986

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