A sequence analysis system encompassing rules for DNA helical distortion

Bruce A. Shapiro; Ruth Nussinov; Lewis E. Lipkin; Jacob V. Maizel

doi:10.1093/nar/14.1.75

A sequence analysis system encompassing rules for DNA helical distortion

Bruce A. Shapiro^*, Ruth Nussinov, Lewis E. Lipkin, Jacob V. Maizel

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Recently, it has been shown by Calladine (1982) and Dickerson (1983) that DNA distortions due to steric clashes between opposing purines and pyrimidines can be quantitated based upon four sum functions. The distortions involve helical twist, roll, torsion angle variations and propeller twist. It is the contention of the authors that these perturbations in structure act as information carriers for various external DNA interactions. This paper describes a system that incorporates these four rules and various other functions that permit the systematic interactive exploration for significant patterns as a consequence of these steric clashes.

Original language	English
Pages (from-to)	75-86
Number of pages	12
Journal	Nucleic Acids Research
Volume	14
Issue number	1
DOIs	https://doi.org/10.1093/nar/14.1.75
State	Published - 10 Jan 1986

Access to Document

10.1093/nar/14.1.75

Cite this

@article{613623f9378d455e816fed5bc3152328,

title = "A sequence analysis system encompassing rules for DNA helical distortion",

abstract = "Recently, it has been shown by Calladine (1982) and Dickerson (1983) that DNA distortions due to steric clashes between opposing purines and pyrimidines can be quantitated based upon four sum functions. The distortions involve helical twist, roll, torsion angle variations and propeller twist. It is the contention of the authors that these perturbations in structure act as information carriers for various external DNA interactions. This paper describes a system that incorporates these four rules and various other functions that permit the systematic interactive exploration for significant patterns as a consequence of these steric clashes.",

author = "Shapiro, {Bruce A.} and Ruth Nussinov and Lipkin, {Lewis E.} and Maizel, {Jacob V.}",

year = "1986",

month = jan,

day = "10",

doi = "10.1093/nar/14.1.75",

language = "אנגלית",

volume = "14",

pages = "75--86",

journal = "Nucleic Acids Research",

issn = "0305-1048",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - A sequence analysis system encompassing rules for DNA helical distortion

AU - Shapiro, Bruce A.

AU - Nussinov, Ruth

AU - Lipkin, Lewis E.

AU - Maizel, Jacob V.

PY - 1986/1/10

Y1 - 1986/1/10

N2 - Recently, it has been shown by Calladine (1982) and Dickerson (1983) that DNA distortions due to steric clashes between opposing purines and pyrimidines can be quantitated based upon four sum functions. The distortions involve helical twist, roll, torsion angle variations and propeller twist. It is the contention of the authors that these perturbations in structure act as information carriers for various external DNA interactions. This paper describes a system that incorporates these four rules and various other functions that permit the systematic interactive exploration for significant patterns as a consequence of these steric clashes.

AB - Recently, it has been shown by Calladine (1982) and Dickerson (1983) that DNA distortions due to steric clashes between opposing purines and pyrimidines can be quantitated based upon four sum functions. The distortions involve helical twist, roll, torsion angle variations and propeller twist. It is the contention of the authors that these perturbations in structure act as information carriers for various external DNA interactions. This paper describes a system that incorporates these four rules and various other functions that permit the systematic interactive exploration for significant patterns as a consequence of these steric clashes.

UR - http://www.scopus.com/inward/record.url?scp=0023045763&partnerID=8YFLogxK

U2 - 10.1093/nar/14.1.75

DO - 10.1093/nar/14.1.75

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 3753794

AN - SCOPUS:0023045763

SN - 0305-1048

VL - 14

SP - 75

EP - 86

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 1

ER -

A sequence analysis system encompassing rules for DNA helical distortion

Abstract

Access to Document

Other files and links

Fingerprint

Cite this