TY - JOUR
T1 - A semi-stochastic cell-based model for in vitro infected 'wound' healing through motility reduction
T2 - A simulation study
AU - Vermolen, F. J.
AU - Gefen, A.
PY - 2013/2/7
Y1 - 2013/2/7
N2 - We consider the migration and viability of individual cells in bacterial-infected cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the motion and viability of each individual cell in a cell colony, and the formalism was published in an earlier paper. The present innovations are an application to a simulation of a 'wound healing assay' in which bacteria infect the wound through impairing the motility of cells and an extension with effects from inertia. Though based on simple principles, the model is based on experiments on living fibroblasts on a flat substrate.
AB - We consider the migration and viability of individual cells in bacterial-infected cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the motion and viability of each individual cell in a cell colony, and the formalism was published in an earlier paper. The present innovations are an application to a simulation of a 'wound healing assay' in which bacteria infect the wound through impairing the motility of cells and an extension with effects from inertia. Though based on simple principles, the model is based on experiments on living fibroblasts on a flat substrate.
KW - Cell colony model
KW - In vitro experiments
KW - Infected wound healing
KW - Semi-stochastic model
UR - http://www.scopus.com/inward/record.url?scp=84870325150&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2012.11.007
DO - 10.1016/j.jtbi.2012.11.007
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AN - SCOPUS:84870325150
SN - 0022-5193
VL - 318
SP - 68
EP - 80
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
ER -