Abstract
We consider the movement and viability of individual cells in cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the displacement and viability of each individual cell in a cell colony. Several applications are shown, such as the dynamics of filling a gap within a fibroblast colony and the invasion of a cell colony. Though based on simple principles, the model is qualitatively validated by experiments on living fibroblasts on a flat substrate.
| Original language | English |
|---|---|
| Pages (from-to) | 183-195 |
| Number of pages | 13 |
| Journal | Biomechanics and Modeling in Mechanobiology |
| Volume | 11 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 2012 |
Keywords
- Cell migration
- Cell-based model
- Semi-stochastic model