A selective increase in plasma soluble vascular cell adhesion molecule-1 levels in preeclampsia

Yair Daniel, Michael J. Kupferminc, Amiram Baram, Eli Geva, Gideon Fait, Joseph B. Lessing

Research output: Contribution to journalArticlepeer-review

Abstract

PROBLEM: The study was conducted to determine whether altered plasma levels of soluble intercellular adhesion molecule (ICAM)-1 and soluble vascular cell adhesion molecule (VCAM)-1 are involved in the pathogenesis of preeclampsia. METHOD OF STUDY: Maternal plasma samples were collected from 20 patients with preeclampsia, 20 matched normotensive patients with uncomplicated pregnancies, and ten healthy nonpregnant women. Samples were assayed for soluble VCAM-1 and soluble ICAM-1 by specific enzyme-linked immunosorbent assay. RESULTS: Both soluble VCAM-1 and soluble ICAM-1 were detectable in the plasma of all preeclamptic, normotensive pregnant, and nonpregnant women. The mean plasma level of soluble VCAM-1 was significantly higher in preeclamptic women compared to normotensive pregnant women (1831 ng/mL ± 534 ng/mL vs. 1254 ng/mL ± 386 ng/mL, respectively; P < 0.05). However, the plasma level of soluble VCAM-1 was unchanged during the third-trimester of normal pregnancy compared to nonpregnant women. The mean plasma level of soluble ICAM-1 in preeclamptic and normotensive pregnant women were increased when compared to nonpregnant women. However, the mean plasma level of soluble ICAM-1 was comparable in women with preeclampsia and normotensive pregnancy. CONCLUSIONS: The selective increased plasma levels of soluble VCAM-1 in patients with preeclampsia provide evidence for endothelial activation and suggest distinct pathways for neutrophil and endothelial activation in preeclampsia.

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume41
Issue number6
DOIs
StatePublished - Jun 1999

Keywords

  • Endothelial activation
  • Neutrophil activation
  • Preeclampsia
  • Soluble ICAM-1
  • Soluble VCAM-1

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