A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia

G. Rechavi, N. Katzir, F. Brok-Simoni, F. Holtzman, M. Mandel, N. Gurfinkel, D. Givol, I. Ben-Bassat, B. Ramot

Research output: Contribution to journalArticlepeer-review

Abstract

Three cellular or putative oncogenes: c-myc, bcl1, and bcl2 were previously found to be rearranged in some B cell malignancies due to chromosomal translocations. Data concerning the role of such genetic rearrangements in B-CLL are very scanty and limited to few cases in which bcl1 rearrangements were found. We studied DNA samples from 38 cases of B-CLL by Southern blot technique in order to find out the existence and frequency of such events. No bcl1 or bcl2 rearrangements were found in any of the studied cases; thus, involvement of these genes in CLL must be rare. In one patient who had an aggressive and resistant disease, c-myc rearrangement was found.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalLeukemia
Volume3
Issue number1
StatePublished - 1989
Externally publishedYes

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