A review of the 2021/2022 PGDIS Position Statement on the transfer of mosaic embryos

on behalf of the International Do No Harm Group in IVF (IDNHG-IVF)

Research output: Contribution to journalReview articlepeer-review

Abstract

The practice of preimplantation genetic testing for aneuploidy (PGT-A) in association with in vitro fertilization (IVF) since 2016 has been mostly directed by three highly controversial guidance documents issued by the Preimplantation Genetic Diagnosis International Society (PGDIS). Because these documents are so influential on worldwide IVF practice, the most recent one is here the subject of a detailed review, again revealing important misrepresentations and internal contradictions. Most importantly, however, this most recent guidance document still does not prevent the non-use and/or disposal of large numbers of embryos with substantial pregnancy and live-birth potential and, therefore, continues to propagate an IVF practice harmful to many infertile women.

Original languageEnglish
Pages (from-to)817-826
Number of pages10
JournalJournal of Assisted Reproduction and Genetics
Volume40
Issue number4
DOIs
StatePublished - Apr 2023

Keywords

  • Embryo mosaicism
  • Guidelines
  • In vitro fertilization (IVF)
  • Preimplantation genetic testing for aneuploid (PGT-a)

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