TY - JOUR
T1 - A review of the 2021/2022 PGDIS Position Statement on the transfer of mosaic embryos
AU - on behalf of the International Do No Harm Group in IVF (IDNHG-IVF)
AU - Gleicher, Norbert
AU - Mochizuki, Lyka
AU - Barad, David H.
AU - Patrizio, Pasquale
AU - Orvieto, Raoul
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/4
Y1 - 2023/4
N2 - The practice of preimplantation genetic testing for aneuploidy (PGT-A) in association with in vitro fertilization (IVF) since 2016 has been mostly directed by three highly controversial guidance documents issued by the Preimplantation Genetic Diagnosis International Society (PGDIS). Because these documents are so influential on worldwide IVF practice, the most recent one is here the subject of a detailed review, again revealing important misrepresentations and internal contradictions. Most importantly, however, this most recent guidance document still does not prevent the non-use and/or disposal of large numbers of embryos with substantial pregnancy and live-birth potential and, therefore, continues to propagate an IVF practice harmful to many infertile women.
AB - The practice of preimplantation genetic testing for aneuploidy (PGT-A) in association with in vitro fertilization (IVF) since 2016 has been mostly directed by three highly controversial guidance documents issued by the Preimplantation Genetic Diagnosis International Society (PGDIS). Because these documents are so influential on worldwide IVF practice, the most recent one is here the subject of a detailed review, again revealing important misrepresentations and internal contradictions. Most importantly, however, this most recent guidance document still does not prevent the non-use and/or disposal of large numbers of embryos with substantial pregnancy and live-birth potential and, therefore, continues to propagate an IVF practice harmful to many infertile women.
KW - Embryo mosaicism
KW - Guidelines
KW - In vitro fertilization (IVF)
KW - Preimplantation genetic testing for aneuploid (PGT-a)
UR - http://www.scopus.com/inward/record.url?scp=85150187285&partnerID=8YFLogxK
U2 - 10.1007/s10815-023-02763-6
DO - 10.1007/s10815-023-02763-6
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C2 - 36892704
AN - SCOPUS:85150187285
SN - 1058-0468
VL - 40
SP - 817
EP - 826
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 4
ER -