A reinvestigation of maprounea triterpenes

John A. Beutler, Yoel Kashman, John H. Cardellina, Glenn N. Gray, Michael J. Currens, Michael R. Boyd*, Mark Tischler, Monroe E. Wall, Mansukh C. Wani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group.

Original languageEnglish
Pages (from-to)1039-1046
Number of pages8
JournalJournal of Natural Products
Issue number7
StatePublished - Jul 1995
Externally publishedYes


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