A reinvestigation of maprounea triterpenes

John A. Beutler; Yoel Kashman; John H. Cardellina; Glenn N. Gray; Michael J. Currens; Michael R. Boyd; Mark Tischler; Monroe E. Wall; Mansukh C. Wani

doi:10.1021/np50121a008

A reinvestigation of maprounea triterpenes

John A. Beutler, Yoel Kashman, John H. Cardellina, Glenn N. Gray, Michael J. Currens, Michael R. Boyd^*, Mark Tischler, Monroe E. Wall, Mansukh C. Wani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group.

Original language	English
Pages (from-to)	1039-1046
Number of pages	8
Journal	Journal of Natural Products
Volume	58
Issue number	7
DOIs	https://doi.org/10.1021/np50121a008
State	Published - Jul 1995
Externally published	Yes

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10.1021/np50121a008

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title = "A reinvestigation of maprounea triterpenes",

abstract = "Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group.",

author = "Beutler, {John A.} and Yoel Kashman and Cardellina, {John H.} and Gray, {Glenn N.} and Currens, {Michael J.} and Boyd, {Michael R.} and Mark Tischler and Wall, {Monroe E.} and Wani, {Mansukh C.}",

year = "1995",

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doi = "10.1021/np50121a008",

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AU - Beutler, John A.

AU - Kashman, Yoel

AU - Cardellina, John H.

AU - Gray, Glenn N.

AU - Currens, Michael J.

AU - Boyd, Michael R.

AU - Tischler, Mark

AU - Wall, Monroe E.

AU - Wani, Mansukh C.

PY - 1995/7

Y1 - 1995/7

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AB - Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group.

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A reinvestigation of maprounea triterpenes

Abstract

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