A novel and simple strategy for preparing a redox-responsive supramolecular hydrogel coassembled from phenylalanine derivative gelator and 4,4′-dipyridine disulfide is reported in this study. The driving force for the coassembly process is intermolecular hydrogen bonds, as confirmed by various characterization methods, such as 1H NMR, Fourier transform infrared (FTIR) spectroscopy, and circular dichroism spectroscopy. The disulfide-containing nanofibrous hydrogel is able to control over the release of encapsulated dyes in response to the reductive condition mimicking the intracellular environment like tumor tissues and should be a promising system for controllable drug release in the fields of nanomedicine and cancer therapy. Redox-responsive supramolecular hydrogels coassembled from small organic molecules are constructed using a novel and easy approach. The ability of the nanofibrous hydrogel to encapsulate a controllable-release model drug under the reductive condition mimicking the intracellular environment is demonstrated. The results suggest the redox-responsive coassembled hydrogel holds great promise as a drug carrier for controllable drug release in nanomedicine and cancer therapy.
- drug release
- supramolecular hydrogels