A Rare Case of Renal Sarcoma Mimicking Metastatic Osteosarcoma

Rennen Haramaty; Eddie Fridman; Ignat Schwartz; Haim Huri; Yoram Mor; Alon Lazarovich

doi:10.1016/j.urology.2024.06.004

A Rare Case of Renal Sarcoma Mimicking Metastatic Osteosarcoma

Rennen Haramaty, Eddie Fridman, Ignat Schwartz, Haim Huri, Yoram Mor, Alon Lazarovich^*

^*Corresponding author for this work

Surgery

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Pediatric renal sarcomas are exceedingly rare entities that present diagnostic challenges. We report a remarkable case of a 14-month-old female with an 8 cm right renal mass, accompanied by disseminated bone metastases, posing intricate clinical and histopathological dilemmas. Initial suspicion leaned towards clear cell sarcoma of the kidney (CCSK), however, subsequent histological examination post-chemotherapy revealed high-grade osteosarcoma and further differential considerations arose, including primary renal osteosarcoma and osseous osteosarcoma with secondary renal involvement. Despite inconclusive histology, treatment proceeded with the UH1 chemotherapy protocol for CCSK, incorporating high-dose Methotrexate for potential osteosarcoma, and the patient demonstrated a favorable response to therapy.

Original language	English
Pages (from-to)	e17-e20
Journal	Urology
Volume	190
DOIs	https://doi.org/10.1016/j.urology.2024.06.004
State	Published - Aug 2024

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10.1016/j.urology.2024.06.004

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abstract = "Pediatric renal sarcomas are exceedingly rare entities that present diagnostic challenges. We report a remarkable case of a 14-month-old female with an 8 cm right renal mass, accompanied by disseminated bone metastases, posing intricate clinical and histopathological dilemmas. Initial suspicion leaned towards clear cell sarcoma of the kidney (CCSK), however, subsequent histological examination post-chemotherapy revealed high-grade osteosarcoma and further differential considerations arose, including primary renal osteosarcoma and osseous osteosarcoma with secondary renal involvement. Despite inconclusive histology, treatment proceeded with the UH1 chemotherapy protocol for CCSK, incorporating high-dose Methotrexate for potential osteosarcoma, and the patient demonstrated a favorable response to therapy.",

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AU - Mor, Yoram

AU - Lazarovich, Alon

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AB - Pediatric renal sarcomas are exceedingly rare entities that present diagnostic challenges. We report a remarkable case of a 14-month-old female with an 8 cm right renal mass, accompanied by disseminated bone metastases, posing intricate clinical and histopathological dilemmas. Initial suspicion leaned towards clear cell sarcoma of the kidney (CCSK), however, subsequent histological examination post-chemotherapy revealed high-grade osteosarcoma and further differential considerations arose, including primary renal osteosarcoma and osseous osteosarcoma with secondary renal involvement. Despite inconclusive histology, treatment proceeded with the UH1 chemotherapy protocol for CCSK, incorporating high-dose Methotrexate for potential osteosarcoma, and the patient demonstrated a favorable response to therapy.

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A Rare Case of Renal Sarcoma Mimicking Metastatic Osteosarcoma

Abstract

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