A rapid method for measuring miotic activity of drugs in the intact mouse eye

G. Treister, S. Maayani, M. Sokolovsky

Research output: Contribution to journalArticlepeer-review

Abstract

A rapid and precise method for evaluating the miotic acitivity of chlinergic drugs was developed based on Long's method for measuring the rate of mydriasis. The rate of reversal of mydriasis developed previously in the intact mouse eye by a mild mydriatic (phencyclidine) is used to evaluate the miotic activity. The method provides a useful tool for measuring and comparing the miotic activity of acetylcholine agonists and cholinesterase inhibitors.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalInvestigative Ophthalmology
Volume14
Issue number2
StatePublished - 1975

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