A randomized-controlled trial assessing the effect of intraoperative acupuncture on anesthesia-related parameters during gynecological oncology surgery

Eran Ben-Arye*, Irena Hirsh, Yakir Segev, Michael Grach, Viraj Master, Arie Eden, Noah Samuels, Nili Stein, Orit Gressel, Ludmila Ostrovsky, Galit Galil, Meirav Schmidt, Elad Schiff, Ofer Lavie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Context and objectives: The present study examined the impact of intraoperative acupuncture on anesthesia-related parameters in patients undergoing gynecological oncology surgery. Methods: Participants underwent preoperative integrative oncology (IO) touch/relaxation treatments, followed by intraoperative acupuncture (Group A); preoperative IO treatments without acupuncture (Group B); or standard care only (Group C). Mean arterial pressure (MAP), heart rate (HR), MAP variability (mean of MAP standard deviation), bispectral index (BIS), and calculated blood pressure Average Real Variability (ARV) were measured intraoperatively. Results: A total of 91 patients participated: Group A, 41; Group B, 24; Group C, 26. Among patients undergoing open laparotomy, Group A showed lower and more stable MAP and HR compared to Group B, (MAP, p = 0.026; HR, p = 0.029) and Group C (MAP, p = 0.025). Mean BIS, from incision to suture closing, was lower in Group A (vs. controls, p = 0.024). In patients undergoing laparoscopic surgery, MAP was elevated within Group A (p = 0.026) throughout surgery, with MAP variability significantly higher in Group A (P = 0.023) and Group B (P = 0.013) 10 min post-incision (vs. pre-incision). All groups showed similar intraoperative and post-anesthesia use of analgesic medication. Conclusion: Intraoperative acupuncture was shown to reduce and stabilize MAP and HR, and reduce BIS in gynecology oncology patients undergoing laparotomy, with no impact on perioperative analgesic medication use. In the laparoscopic setting, intraoperative acupuncture was associated with elevated MAP. Further research is needed to explore the hemodynamic and BIS-associated benefits and risks of intraoperative acupuncture, and the impact on the use of analgesic drugs in response to these changes.

Original languageEnglish
Pages (from-to)8177-8189
Number of pages13
JournalJournal of Cancer Research and Clinical Oncology
Volume149
Issue number11
DOIs
StatePublished - Sep 2023
Externally publishedYes

Funding

FundersFunder number
Israel Cancer Association20180006

    Keywords

    • Acupuncture
    • Gynecological oncology
    • Integrative medicine
    • Integrative oncology
    • Intraoperative
    • Pain

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