@article{bc1bb09f6ef74e78b3cd66b85837f6c0,
title = "A qualitative difference in the interleukin 2 (IL-2) requirement of helper and cytotoxic T lymphocytes",
abstract = "A qualitative difference in the requirement of mouse helper and cytotoxic T lymphocytes for interleukin 2 (IL-2) was revealed by offering such cells IL-2 synthesized in Xenopus laevis oocytes that had been microinjected with messenger RNA (mRNA) encoding human IL-2. While both helper and cytotoxic mouse T-cell lines proliferate in response to the IL-2 present in medium conditioned by stimulated human lymphocytes, only helper-T-cell lines respond to human IL-2 secreted from oocytes. This result demonstrates a difference between helper and cytotoxic T lymphocytes in their response to IL-2. The growth response of murine cells shows that IL-2 secreted from human cells has properties not found in the IL-2 secreted from oocytes, even though a monoclonal antibody directed against the human IL-2 receptor blocks the activity of both types of IL-2. Quite possibly, ths difference results from a post-translational modification.",
author = "Shimon Efrat and Raymond Kaempfer",
note = "Funding Information: We thank Dr. E. Mazes, Dr. 0. Axelrod, Dr. E. Kedar and Dr. J. D. Watson for cell lines, Dr. T. A. Waldmann for monoclonal antibody, and Dr. E. Mozes for helpful discussion. Supported by a grant from the National Council for Research and Development, Israel.",
year = "1984",
month = oct,
day = "1",
doi = "10.1016/0008-8749(84)90065-0",
language = "אנגלית",
volume = "88",
pages = "207--212",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",
}