TY - CHAP
T1 - A protocol for the design of protein and peptide nanostructure self-assemblies exploiting synthetic amino acids
AU - Haspel, Nurit
AU - Zheng, Jie
AU - Aleman, Carlos
AU - Zanuy, David
AU - Nussinov, Ruth
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2017.
PY - 2017
Y1 - 2017
N2 - In recent years there has been increasing interest in nanostructure design based on the self-assembly properties of proteins and polymers. Nanodesign requires the ability to predictably manipulate the properties of the self-assembly of autonomous building blocks, which can fold or aggregate into preferred conformational states. The design includes functional synthetic materials and biological macromolecules. Autonomous biological building blocks with available 3D structures provide an extremely rich and useful resource. Structural databases contain large libraries of protein molecules and their building blocks with a range of sizes, shapes, surfaces, and chemical properties. The introduction of engineered synthetic residues or short peptides into these building blocks can greatly expand the available chemical space and enhance the desired properties. Herein, we summarize a protocol for designing nanostructures consisting of selfassembling building blocks, based on our recent works. We focus on the principles of nanostructure design with naturally occurring proteins and synthetic amino acids, as well as hybrid materials made of amyloids and synthetic polymers.
AB - In recent years there has been increasing interest in nanostructure design based on the self-assembly properties of proteins and polymers. Nanodesign requires the ability to predictably manipulate the properties of the self-assembly of autonomous building blocks, which can fold or aggregate into preferred conformational states. The design includes functional synthetic materials and biological macromolecules. Autonomous biological building blocks with available 3D structures provide an extremely rich and useful resource. Structural databases contain large libraries of protein molecules and their building blocks with a range of sizes, shapes, surfaces, and chemical properties. The introduction of engineered synthetic residues or short peptides into these building blocks can greatly expand the available chemical space and enhance the desired properties. Herein, we summarize a protocol for designing nanostructures consisting of selfassembling building blocks, based on our recent works. We focus on the principles of nanostructure design with naturally occurring proteins and synthetic amino acids, as well as hybrid materials made of amyloids and synthetic polymers.
KW - Amyloid peptides
KW - Beta-helical proteins
KW - Computational nanodesign
KW - Hybrid materials
KW - Nanostructures
KW - Peptide-based nanodesign
KW - Self-assembly
KW - Synthetic amino acids
UR - http://www.scopus.com/inward/record.url?scp=85005949759&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-6637-0_17
DO - 10.1007/978-1-4939-6637-0_17
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C2 - 27914060
AN - SCOPUS:85005949759
T3 - Methods in Molecular Biology
SP - 323
EP - 352
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -