@article{51a316a167e246e1862e704df7b64fcc,
title = "A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair",
abstract = "Molecular mechanisms that regulate lung repair vs. progressive scarring in pulmonary fibrosis remain elusive. Interleukin (IL)-4 and IL-13 are pro-fibrotic cytokines that share common receptor chains including IL-13 receptor (R) α1 and are key pharmacological targets in fibrotic diseases. However, the roles of IL-13Rα1 in mediating lung injury/repair are unclear. We report dysregulated levels of IL-13 receptors in the lungs of bleomycin-treated mice and to some extent in idiopathic pulmonary fibrosis patients. Transcriptional profiling demonstrated an epithelial cell-associated gene signature that was homeostatically dependent on IL-13Rα1 expression. IL-13Rα1 regulated a striking array of genes in the lung following bleomycin administration and Il13ra1 deficiency resulted in exacerbated bleomycin-induced disease. Increased pathology in bleomycin-treated Il13ra1 -/- mice was due to IL-13Rα1 expression in structural and hematopoietic cells but not due to increased responsiveness to IL-17, IL-4, IL-13, increased IL-13Rα2 or type 1 IL-4R signaling. These data highlight underappreciated protective roles for IL-13Rα1 in lung injury and homeostasis.",
author = "D. Karo-Atar and A. Bordowitz and O. Wand and M. Pasmanik-Chor and Fernandez, {I. E.} and M. Itan and R. Frenkel and Herbert, {D. R.} and Finkelman, {F. D.} and O. Eickelberg and A. Munitz",
note = "Funding Information: This study was supported by research funding to AM by the FP7 Marie-Curie Reintegration grant (grant no. 256311), the US-Israel Binational Science Foundation (grant nos. 2009222 and 2011244), the Israel Science Foundation (grant no. 955/11), the Israel Cancer Research Foundation (ICRF) Research Career Development Award (RCDA), The Fritz Thyssen Stiftung, and The Tel-Aviv University Stolz Award, and research funding to FDF from the U.S. Department of Veterans Affairs. Danielle Karo-Atar performed this work in partial fulfillment of the requirements for a PhD degree at the Sackler Faculty of Medicine, Tel-Aviv University, Israel. We thank Dr. Katharina Heinzelmann for her technical assistance.",
year = "2016",
month = jan,
day = "1",
doi = "10.1038/mi.2015.56",
language = "אנגלית",
volume = "9",
pages = "240--253",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "Elsevier B.V.",
number = "1",
}
