A prospective study of C-reactive protein in patients with obesity during IVF

Einat Haikin Herzberger*, Netanella Miller, Yehudith Ghetler, Rina Tamir Yaniv, Eran Neumark, Adrian Shulman, Amir Wiser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This prospective cohort pilot study investigated the physiology of C-reactive protein (CRP) during in vitro fertilization (IVF) cycles and its effect on outcomes in women with and without obesity. The study was conducted from April to August 2014, in the IVF Unit of a university-affiliated hospital. Women aged 18–42 years were enrolled. Those with chronic inflammatory diseases or acute illness were excluded. A total of 31 patients were included: 17 with BMI < 30 kg/m2 and 14 with BMI ≥ 30 kg/m2. Serum CRP levels were measured: (i) before starting ovarian stimulation; (ii) on the day of β-HCG administration; and (iii) on day of ovum pick-up (OPU), in both serum and follicular fluid. Serum CRP levels were significantly higher in women with obesity at all time points. For the entire cohort, a positive correlation was found between basal oestradiol (E2) and basal CRP (r = 0.71, p < 0.05). A specific pattern of CRP levels was not detected during the IVF cycle. High serum CRP levels on OPU day had a negative effect on embryo quality (p = 0.056). CRP ≥ 0.5 mg/dL was associated with lower quality embryos (2.6 ± 0.3 vs. 3.3 ± 0.3; p = 0.04). High serum CRP level on OPU day negatively affects embryo quality.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalHuman Fertility
Issue number3
StatePublished - 2021


  • C-reactive protein
  • In vitro fertilization
  • Obesity
  • follicular fluid
  • ovarian stimulation


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